Dietary Fatty Acids, PPAR Activated Genes and Coronary Heart Disease in Costa Rica
Coronary heart disease (CHD) is the major cause of death in most industrialized and developing countries. Links between genetic and dietary factors that modify the risk of CHD should give fundamental insight into its causes and improve population-based CHP prevention strategies. This study proposes to identify genes that modulate the association between dietary fatty acids (FAs) and myocardial infarction (MI). The study will use DNA samples obtained during a population-based, case-control study in Costa Rica of 2,150 subjects who experienced MI and 2,150 matched controls. The study will use gene-diet association studies and a candidate pathway approach to elucidate genetic mechanisms that link risk of MI with exposure to polyunsaturated FAs. The study will focus on peroxisome proliferator-activated receptor (PPAR) genes, and PPAR-regulated genes that are involved in vascular inflammation. Among controls, the study will examine whether genetic and dietary factors independently affect biochemical markers (phenotypes) of the proposed genes, and whether these phenotypes are more clearly identified when genetic and dietary factors are examined together.
Participating Harvard faculty: Hannia Campos, Senior Lecturer on Nutrition, Harvard School of Public Health